Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture
نویسندگان
چکیده
Mixed lymphocyte reaction (MLR)-activated T cells were analyzed according to the expression of various cell surface markers by the specific cytotoxic T lymphocytes (CTL) generated in the MLR. CTL were found exclusively in a population of MLR-activated T cells that lacked detectable Fc gamma R but that expressed a surface antigen recognized by the 4F2 monoclonal antibody. In contrast, CTL were found in both the Ia-positive and Ia-negative cells after MLR activation. Thus, the specific CTL generated in the allogeneic MLR can be identified and isolated by virtue of the expression of a particular cell surface marker.
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 153 شماره
صفحات -
تاریخ انتشار 1981